If you find yourself constantly changing the Page Layout everytime you open a PDF file, you should consider changing your default page layout. For instance, you may prefer viewing the PDF using the Two-Up layout (especially if you use a wide-screen monitor).
1. Open Adobe Reader.
2. Go to the menu, click Edit and select Preferences.
3. Under Categories, select Page Display.
4. On the right, in the Default Layout and Zoom section, use the Page Layout dropdown to select the new default layout. Choices are Automatic, Single Page, Single Page Continuous, Two-Up, and Two-Up Continuous.
5. Click the OK button.